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  Micah Hyde, Jordan Poyer highlighted among best NFL defensive 'duos' by PFF USA TODAY - June 25th, 2022        The highest-graded Bills receivers during the PFF era is a (mostly) fun list USA TODAY - June 24th, 2022   PFF: DaQuan Jones should have 'inside track' for starting snaps with Bills USA TODAY - June 24th, 2022     
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| AFC EAST | ||||
| TEAM | W | L | T | PCT |
| Bills | 11 | 6 | 0 | 0.647 |
| Patriots | 10 | 7 | 0 | 0.588 |
| Dolphins | 9 | 8 | 0 | 0.529 |
| Jets | 4 | 13 | 0 | 0.235 |
| Patriots Previous 20 Meetings: (*Regular Season) | ||
| 12/26/2021 vs Bills | 21-33 | (L) |
| 12/06/2021 at Bills | 14-10 | (W) |
| 12/28/2020 vs Bills | 9-38 | (L) |
| 11/01/2020 at Bills | 21-24 | (L) |
| 12/21/2019 vs Bills | 24-17 | (W) |
| 09/29/2019 at Bills | 16-10 | (W) |
| 12/23/2018 vs Bills | 24-12 | (W) |
| 10/29/2018 at Bills | 25-6 | (W) |
| 12/24/2017 vs Bills | 37-16 | (W) |
| 12/03/2017 at Bills | 23-3 | (W) |
| 10/30/2016 at Bills | 41-25 | (W) |
| 10/02/2016 vs Bills | 0-16 | (L) |
| 11/23/2015 vs Bills | 20-13 | (W) |
| 09/20/2015 at Bills | 40-32 | (W) |
| 12/28/2014 vs Bills | 9-17 | (L) |
| 10/12/2014 at Bills | 37-22 | (W) |
| 12/29/2013 vs Bills | 34-20 | (W) |
| 09/08/2013 at Bills | 23-21 | (W) |
| 11/11/2012 vs Bills | 37-31 | (W) |
| 09/30/2012 at Bills | 52-28 | (W) |
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